Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 12 2 2013 06 15 115 123 EN María Morales Suárez-Varela Public and Environmental Health Unit, Department of Preventive Medicine, University of Valencia, CIBER Epidemiology and Public Health (CIBERESP), and Center for Public Health Research (CSISP), Valencia, Spain Luís García-Marcos Pediatric Respiratory and Allergy Units, “Arrixaca” University Children’s Hospital, University of Murcia, and CIBER of Epidemiology and Public Health (CIBERSP), Murcia, Spain Javier Fuertes Fernández-Espinar Perpetuo Socorro” Health Center, Huesca, Spain Alberto Bercedo-Sanz Meruelo” Health Center, Santander, Spain Inés Aguinaga-Ontoso Department of Health Sciences, Public University of Navarra, Pamplona, Spain Carlos González-Díaz Department of Pediatrics, Basurto Hospital, Bilbao, Spain Ignacio Carvajal-Urueña La Ería” Health Center, Oviedo, Asturias Princedom Health Service, Asturias, Spain Rosa María Busquet-Monge Department of Pediatrics, Hospital del Mar, Barcelona, Spain Alberto Arnedo-Pena Centre of Public Health, Regional Health Authority, Castellón, Spain Nagore García de Andoin Department of Pediatrics, “Donostia” Hospital, San Sebastián, Guipuzcoa, Spain José Batlles-Garrido Department of Pediatrics, “Torrecárdenas” Hospital, Almería, Spain Alfredo Blanco-Quirós Department of Pediatrics, University of Valladolid, Spain Angel López-Silvarrey Varela María José Jove Foundation, La Coruña, Spain Gloria García-Hernández Pediatric Allergy and Pulmonology Unit. “12 de Octubre” University Children’s Hospital, Madrid, Spain Natalia Gimeno-Clemente Public and Environmental Health Unit, Department of Preventive Medicine, University of Valencia, CIBER Epidemiology and Public Health (CIBERESP), and Center for Public Health Research (CSISP), Valencia, Spain Nuria Rubio-López Public and Environmental Health Unit, Department of Preventive Medicine, University of Valencia, CIBER Epidemiology and Public Health (CIBERESP), and Center for Public Health Research (CSISP), Valencia, Spain Agustín Llopis-González Public and Environmental Health Unit, Department of Preventive Medicine, University of Valencia, CIBER Epidemiology and Public Health (CIBERESP), and Center for Public Health Research (CSISP), Valencia, Spain 2015 10 16 Atopic Eczema (AE) is a chronic inflammatory skin disease that affects children and adults, and  alters  quality  of  life.  Previous  studies  have suggested several  socio-demographic   and environmental factors related to the prevalence of AE and other allergic diseases,  including acetaminophen use. In the present study, we report the rates of isolated AE, AE associated with asthma and AE associated with rhinitis among 13- to 14-year-old Spanish adolescents and the level of association of these conditions with the use of acetaminophen. We analyzed Spanish data from a cross-sectional Phase 3 study within ISAAC. A total of 28,717 adolescents completed the Phase 3 written questionnaire by answering questions for acetaminophen use and on asthma, rhinitis and AE symptoms. We observed an association between acetaminophen use and AE among the adolescents who had used acetaminophen in the previous month. Furthermore, the prevalence rate increased with the number of allergic processes: for AE alone, the adjusted Prevalence Ratio (aPR) was 1.81 and for AE associated with rhinitis or with asthma, aPRs were 2.20 and 3.03, respectively. We conclude that acetaminophen use in childhood  may be an important factor associated with development and/or maintenance of AE and other allergic diseases. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/524 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/524/486