Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 12 2 2013 06 15 182 189 EN Parisa Karimi Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Seyedeh Zalfa Modarresi Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Mohammad Ali Sahraian Department of Neurology, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran Raheleh Shokouhi Shoormasti Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Maryam Mahlooji Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran Anoushirvan Kazemnejad Department of Biostatistics, Tarbiat Modares University, Tehran, Iran Zahra Pourpak Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran 2015 10 16 Multiple Sclerosis (MS) and Allergy are believed to up regulate T helper cell type 1 (Th1) and T helper cell type 2 (Th2) responses, respectively. It has been shown that disequilibrium in the  ratio  of  Th1/Th2  activities may increase frequency of  one  disease and  decrease the frequency of the other. The aim of this study was to investigate the relation of MS with allergy and atopy in new diagnosed MS patients. This case-control study was conducted on 40 new diagnosed MS patients and the same number  of  normal controls. All of  the  patients were diagnosed (according to  McDonald criteria) at most 2 years prior to the study. Demographic data and clinical characteristics of both groups were recorded in a questionnaire. The total IgE and allergen specific IgE in the serum were measured in all the cases. Forty MS patients (female/male: 4.71) with mean age of 30.55±9.5 years and 40 healthy controls entered in this study. History of allergy was observed in 20(50%) of MS patients (including 15 (37.5%) rhinitis, 6 (15%) conjunctivitis, 3 (7.5%) urticaria and eczema, 1 (2.5%) asthma), and 20 (50%) of the controls (including 8 (20%) rhinitis, 4 (10%) conjunctivitis, 7 (17.5%) urticaria and eczema, 1 (2.5%) asthma). The differences between the two groups were not  statistically significant. Neither the serum total IgE, nor the frequency of specific IgE against Weed mix, Grass Mix, Tree mix1, Tree mix 2, Dermatophagoides Farinae, Dermatophagoides pteronyssinus and Epidermal and animal proteins mix differed statistically between the  two  groups. There  was also no  significant relationship between MS clinical manifestations and allergy prevalence and also between MS and atopy.  The results of this study as some other similar studies showed the same prevalence of allergy in MS patients and controls and also demonstrated no relation between MS and atopy. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/515 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/515/518