Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 12 4 2013 12 15 391 396 EN Micheal Shazia Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan AND Department of Ophthalmology, Radboud University Nijmegen Medical Centre; Nijmegen, Netherlands. Minhas Kanza Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan. Ishaque Mehwish Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan. Shabbir Irum Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan. Ahmed Farida National Institute of Health, Islamabad, Pakistan. Ahmed Asifa Department of Biosciences, COMSATS Institute of Information Technology, Islamabad-44000, Pakistan. 2015 10 16 Interleukin-13 (IL-13) is known to be a key regulator in immunoglobulin E (IgE) synthesis, mucus hypersecretion and airway hyperresponsiveness. Single nucleotide polymorphisms in IL-13 are associated with allergic phenotypes in several ethnically diverse populations.This study was performed in 214 atopic patients (asthma n=108, allergic rhinitis n=106) and sex-matched healthy controls (n=120). Genotyping of IL-13 gene polymorphisms was performed using polymerase chain reaction-based restriction fragment length polymorphism method.A statistically significant association of the A-1512C polymorphism in IL13 gene was observed with atopy (p<0.001; χ2=19.0). Upon stratification of the data into asthma and AR association was revealed with both asthma (p=0.01; χ2=8.80) and AR (p<0.001; χ2=24.3) in Pakistani patients. Higher odds ratio (OR 95% CI) was observed for AR 3.42 (2.04-5.76) relative to asthma 2.40 (1.41-4.09) for the C allele compared to controls.In conclusion the study provides the evidence A-1512C polymorphisms in IL-13 is a risk factor for asthma and AR. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/487 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/487/557