Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 0 0 2026 08 28 1 9 Yue  Cui Department of Stomatology, Dongfang Hospital, Beijing University of Chinese Medicine; Beijing, China Hong  Mu Department of Stomatology, Dongfang Hospital, Beijing University of Chinese Medicine; Beijing, China Shuang  Cai Department of Stomatology, Dongfang Hospital, Beijing University of Chinese Medicine; Beijing, China Xuewen Jiao Shanghai Jing'an Dental Clinic; Shanghai, China 2026 04 29 2026 05 25 To evaluate the efficacy of concentrated growth factors (CGF) combined with guided tissue regeneration (GTR) in patients with severe periodontitis. This retrospective study included 220 patients with severe periodontitis undergoing periodontal regenerative surgery. After propensity score matching, 85 patients treated with CGF plus GTR and 85 treated with GTR alone were analyzed. Overall clinical response, postoperative pain, gingival thickness, alveolar bone parameters, and gingival crevicular fluid levels of IL-17, IL-23, and IL-10 were assessed. The CGF group showed a significantly higher overall response rate than the GTR-alone group (94.12% vs 75.29%). Pain scores were significantly lower in the CGF group on postoperative day 1, with no significant differences on days 3 and 7. At 3 months, improvements in gingival thickness, alveolar bone height, width, and gray values were greater in the CGF group, although differences were not significant at 6 months. CGF treatment reduced IL-17 and IL-23 levels and increased IL-10 levels; these changes correlated with improvements in gingival and bone regeneration. CGF combined with GTR may enhance early periodontal tissue regeneration, reduce immediate postoperative pain, and modulate local inflammation in severe periodontitis. Further randomized controlled trials are needed to establish long-term benefits. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/4817 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/4817/2397