Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 2 2014 04 15 Vitamin E Supplementation, Lung Functions and Clinical Manifestations in Children with Moderate Asthma: A Randomized Double Blind Placebo- Controlled Trial 98 103 EN Javad Ghaffari Department of Allergy and Clinical Immunology, Molecular and Cellular Research Center, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Reza Farid Hossiani Department of Allergy and Clinical Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Alireza Khalilian Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran Negin Nahanmoghadam Department of General Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran Ebrahim Salehifar Department of Pharmacology, Mazandaran University of Medical Sciences, Sari, Iran Houshang Rafatpanah Department of Immunology, Mashhad University of Medical Sciences, Mashhad, Iran 2015 10 16 Asthma is the most  common  chronic inflammatory disorder characterized by cough, wheezing and dyspnea in children. Nutrition  is an important  factor which influences on induction and exacerbation of asthma. There are controversies to use Vitamin E in asthmatic patients. The aim of this study was to evaluate the effect of vitamin E supplement in children with moderate asthma. This is a randomized double blind placebo-controlled trial performed on children (age 2-17 years old) with moderate asthma (5-17 years old) from March 2010 to March 2012. Case group were treated with fluticasone and vitamin E (50mg/day) and control group received fluticasone plus placebo for 8 weeks. Out of 300 cases, 240 cases completed the study. Female to male ratio was 0.84. Serum level of Vitamin E significantly increased after treatment in intervention group. FEV1 and FEV1/FVC ratio was ignificantly improved in case group compared to the control group. It can be concluded that vitamin E supplement could improve clinical manifestations and pulmonary function test in children with moderate asthma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/470 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/470/367