Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 0 0 2026 10 11 1 18 Mahdieh Shadian Zarsabzevar Department of Laboratory Sciences, School of Paramedical and Rehabilitation Sciences, Mashhad University of Medical Sciences, Mashhad, Iran Kianush Charoghdoozi Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran AND Department of Immunology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Javad Balighi Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran Yeganeh Khazaei Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran Amirali Ebrahimpour Department of Medical Laboratory Sciences, Varastegan Institute for Medical Sciences, Mashhad, Iran Sajad Dehnavi Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AND Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mahvash Sadeghi Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran AND Innovative Medical Research Center, MMS. C., Islamic Azad University, Mashhad, Iran 2025 11 23 2026 07 01 Allergic asthma considered is a type I hypersensitivity disorder with increasing global prevalence and limited curative options. Mesenchymal stem cells (MSCs) and their exosomes have emerged as promising adjuncts in the control of allergic reactions. MSCs can regulate and shift the inflammatory responses and promote tissue remodeling in the airway tissues. Furthemore, exosomes derived from MSCs contribute to these effects by mediating intercellular communication and delivering bioactive molecules that modulate immune responses. This review discusses current evidence on the immunomodulatory potential and therapeutic benefits of MSCs and their exosomes in the context of allergen-specific immunotherapy (AIT) to enhance efficacy, induce long-lasting tolerance, and address current therapeutic limitations in allergic asthma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/4675 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/4675/2439