Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 0 0 2026 03 12 1 13 Azizollah Yousefi Pediatric Growth and Development Research Center, Institute of Endocrinology and Metabolism, Iran University of Medical Sciences, Tehran, Iran Saeed Sepehry Vafa Department of Pediatrics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Mina Mirzad Department of Pediatrics, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran Fatemeh Elham Mahjoub Department of Pathology, School of Medicine, Maternal, Fetal, and Neonatal Research Center, Family Health Research Institute, Iran University of Medical Sciences, Tehran, Iran Behnam Shahsavand Department of Pediatrics, Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Ebrahim Babaee Department of Community and Family Medicine, Preventive Medicine and Public Health Research Center, Psychosocial Health Research Institute, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Fereshteh Karbasian Department of Pediatric Gastroenterology and Hepatology, Ali-Asghar Children's Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohammad Nabavi Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Mohammad Hasan Bemanian Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Sima Shokri Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Saba Arshi Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran Morteza Fallahpour Department of Allergy, Rasoul-e-Akram Hospital, School of Medicine, Iran University of Medical Sciences, Tehran, Iran 2025 07 17 2025 09 12 Eosinophilic gastrointestinal diseases (EGIDs) are chronic, TH2-mediated conditions. Eosinophilic esophagitis (EoE) is the most common type, while non-EoE EGIDs affect other gut segments. This retrospective study of 111 patients (50 EoE and 61 non-EoE) from 2011 to 2022 compared the clinical aspects of these 2 types. Dysphagia and food impaction dominated in EoE, while abdominal pain, nausea, and diarrhea were more common in non-EoE EGIDs. Atopic comorbidities were frequent. Diagnostic delays>1 year were more common in EoE (72% vs 47.5%). The overall clinical response rate was 88.29%, with most patients using food avoidance (90.99%) and proton pump inhibitors (94.59%). Clinical relapses occurred in 38.88% over the mean follow-up of 4.62 years and were unaffected by therapy type. Failure to thrive was seen in 26.7%, with no significant intergroup difference. This study highlights a prolonged diagnostic delay in EoE vs non-EoE EGIDs. Both groups showed similar, favorable response rates, underscoring a need for greater awareness. Prospective studies with standardized measures are required to optimize management. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/4520 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/4520/2315