Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 4 2014 08 15 286 289 EN Fariborz Zandieh Department of Asthma, Allergy and Immunology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Bahram Mirsaed Ghazi Department of Asthma, Allergy and Immunology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Anahita Izadi Department of Infectiousn Diseases, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mohammad Gharegozlu Department of Infectiousn Diseases, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran. Motahareh Aghajani Department of Asthma, Allergy and Immunology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. Mahdi Sheikh Department of Asthma, Allergy and Immunology, Bahrami Children Hospital, Tehran University of Medical Sciences, Tehran, Iran. 2015 10 16 Papillon-Lefevre syndrome (PLS) is a very rare genetic syndrome, and fewer than 500 cases have been reported in the world. Patients exhibit typical cutaneous involvement with hyperkeratosis, especially on the soles and palms, and early shedding of primary teeth. Internal organ involvements, such as liver abscesses, have been described in case reports. This  communication  represents  the  first  time  that  genetically  documented  PLS  with footprints of mycobacterium tuberculosis in liver and kidney is reported. T-Lymphocyte transformation Test with PHA was abnormal in this patient. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/444 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/444/393