Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 300 306 EN Esmaeil Mortaz Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands AND Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Immunology, ShahidBeheshti  University of Medical Sciences, Tehran, Iran Mohammad Reza Masjedi Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Immunology, ShahidBeheshti University of Medical Sciences, Tehran, Iran. Payam Tabarsi Clinical Tuberculosis and Epidemiology Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran. Mihan Pourabdollah Chronic Respiratory Diseases Research Center and National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Department of Immunology, ShahidBeheshti University of Medical Sciences, Tehran, Iran. Ian M Adcock Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK. 2015 10 16 The immunopathology of sarcoidosis remains elusive despite years of research into this multiorgan disease.However, recent studies have provided new insights into the genetics and immune components involved in the clinical manifestation of the disease. Granulomatous inflammation is due to the host immune response to a persistent poorly degradable unknown antigen.Mycobacterium tuberculosis (MTB) is the major disease driver in many patients. The  immune  mechanisms  that  cause this  disease start  with  the  antigenic stimulus, followed by T-cell, macrophage and dendritic cell activation via a classic MHC II–mediated pathway. In addition, the profile of immune mediators reported in sarcoidosis indicates that the inflammasome pathway plays a critical role in disease pathogenesis. Increased understanding of the signal  ransductions pathways involved in the induction of inflammatory processes in sarcoidosis could give rise to new therapeutic approaches in future. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/440 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/440/397