Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 25 2 2026 02 01 264 268 Tayebeh Ranjbarnejad Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran Mansoor Salehi Cellular, Molecular and Genetics Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Hassan Abolhassani Division of Immunology, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden AND Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center Hospital, Tehran University of Medical Sciences, Tehran, Iran Roya Sherkat Immunodeficiency Diseases Research Center, Isfahan University of Medical Sciences, Isfahan, Iran Mohammadreza Sharifi Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran 2025 02 15 2025 07 13 Common variable immunodeficiency disorder (CVID) is the most prevalent primary immunodeficiency in adults. Pathogenic mutations of the TNFRSF13B gene were identified in CVID patients and associated with autoimmunity and lymphoproliferation. A study on Swedish children unaffected by CVID has shown that rare variants in the TNFRSF13B gene increase the risk of asthma. To the best of our knowledge, asthma has not been reported in CVID patients with TNFRSF13B gene mutations. We described a patient suffering from asthma and CVID with a heterozygous mutation in the TNFRSF13B gene. According to our findings and previous studies, mutations in the TNFRSF13B gene seem to be possibly associated with the occurrence of asthma in CVID patients.  https://ijaai.tums.ac.ir/index.php/ijaai/article/view/4350 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/4350/2229