Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 13 5 2014 10 15 375 377 EN Neslihan Yerebasmaz Department of Obstetrics and Gynecology, Ankara Etlik Zubeyde Hanim AND Women's Health Teaching and Research Hospital, Ankara, Turkey. Ali Kutlu Department of Allergy and Immunology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. Ersin Aydin Department of Dermatovenereology, Kasimpasa Military Hospital, Istanbul, Turkey. Ercan Karabacak Department of Dermatovenereology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. Sami Ozturk Department of Allergy and Immunology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. Ismet Gun Department of Obstetrics and Gynecology, GATA Haydarpasa Teaching Hospital, Istanbul, Turkey. 2015 10 16 Progesterone hypersensitivity (PH) is a rare clinical condition that  displays hypersensitivity to  endogenous  or  exogenous progesterone.  It  is characterized by cyclic dermatologic manifestations at the end of the luteal phase that disappear some days after menses. We present  a  case of  24-year-old woman  showing severe angioedema attacks occurring from the first day of her menstruation and continuing for 4-5 days and having positive progesterone intradermal test (IDT). To our knowledge, there is no case in the literature which is coupled with PH isolated angioedema attacks. In this case report we will discuss diagnostic value of progesterone IDT. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/430 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/430/407