Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 14 1 2015 02 15 37 47 EN Abdolreza Babamahmoodi Health Management Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Zahra Arefnasab Alliant International University, California School of Professional Psychology, California, USA. Ahmad Ali Noorbala Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran. Mostafa Ghanei Pulmonary Diseases, Chemical Injuries Research Center Baqiyatallah university of medical sciences, Tehran, Iran. Farhang Babamahmoodie Infectious Diseases, Anti-Microbial Drug Resistance Research Center, Mazandaran University of Medical Sciences, Sari, Iran. Ahmad Alipour Department of Psychology, Payame Noor University, Tehran, Iran. Mohammad Hossein Alimohammadian Department of Immunology, Pasteur Institute of Iran, Tehran, Iran. Farhad Riazi Rad Department of Immunology, Pasteur Institute of Iran, Tehran, Iran. Vahid Khaze Department of Immunology, Pasteur Institute of Iran, Tehran, Iran. Haideh Darabi Department of Immunology, Pasteur Institute of Iran, Tehran, Iran. 2015 10 16 Emotional Freedom Technique (EFT) as a new therapeutic technique in energy psychology has positive effects on psychological and physiological symptoms, and quality of life. In this research we studied the effect of this treatment on immunological factors. This study tested whether 8-week group sessions of EFT (compared to a wait-list control group) with emphasis on patient's respiratory, psychological and immunological problems in chemically pulmonary injured veterans (N=28) can affect on immunological and psychological factors. Mixed effect linear models indicated that EFT improved mental health (F=79.24, p=0) and health-related quality of life (F=13.89, p=0.001), decreased somatic symptoms (F=5.81, p=0.02), anxiety/insomnia (F=24.03, p<0.001), social dysfunction (F=21.59, p<0.001), frequency and severity of respiratory symptoms (F=20.38, p<0.001), and increased lymphocyte proliferation with nonspecific mitogens Concanavalin A (Con A) (F=14.32, p=0.001) and Phytohemagglutinin (PHA) (F=12.35, p=0.002), and peripheral blood IL-17 (F=9.11, p=0.006). This study provides an initial indication that EFT may be a new therapeutic approach for improving psychological and immunological factors. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/414 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/414/423