Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 22 6 2023 12 28 604 608 EN Linxin Liu Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China Haoxian Gou Department of Hepatobiliary Pancreatic Surgery, School of Clinical Medicine, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan, China Yongfa Liu Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China Shuai Hu Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China Xiaoli Yang The Affiliated Hospital of Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, ChinaMedical University Bo Li Department of General Surgery, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China 2022 11 11 2023 10 20 Kimura disease (KD), also known as eosinophilic lymphogranuloma, is a rare chronic inflammatory or allergic disease. It can present with immune-related diseases such as nephrotic syndrome, asthma, and ankylosing spondylitis. In this study, we report a case of KD combined with immunoglobulin A nephropathy that first presented as a mass in the inguinal region, followed by recurrent renal involvement. Previous reports suggested that renal involvement caused by KD was due to direct infiltration of eosinophils; however, in this case, no eosinophil infiltration was found in the renal tissue after renal biopsy. This observation reminds us to approach the case from an immune-related molecular perspective to investigate the exact cause of renal damage due to KD.  https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3705 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/3705/1996