Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 22 3 2023 06 16 290 298 EN Bin Shang Department of Thoracic Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China AND Department of Thoracic Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Xiangguo Li Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China AND Department of Pulmonary and Critical Care Medicine, The Affiliated Wenling Hospital of Wenzhou Medical University, Taizhou, China Yu Xu Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, China AND Department of Pulmonary and Critical Care Medicine, Jinan Shizhong People’s Hospital, Jinan, China Wenxin Ren Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, China AND Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, China Junren Wang Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, China AND Shandong Key Laboratory of Infectious Respiratory Disease, Jinan, China Chunyan Xing Department of Pulmonary and Critical Care Medicine, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan, China Shujuan Jiang Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China AND Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, China Jian Sun Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China AND Department of Pulmonary and Critical Care Medicine, Shandong Provincial Hospital, Affiliated to Shandong First Medical University, Jinan, Ch 2022 06 24 2023 03 13 Asthma is a common chronic airway inflammation that produces a healthcare burden on the economy. We aim to obtain a better understanding of the clinical status and disease burden of patients with asthma in China. A retrospective study was carried out based on the computerized medical records in the Jinan Health Medical Big Data Platform between 2011 and 2019 (available data from 38 hospitals). The asthma severity of each patient was assessed retrospectively and categorized as mild, moderate, or severe according to Global Initiative for Asthma 2020 (GINA 2020). The results revealed that the majority (75.0%) of patients suffered from mild asthma. Patients treated with inhaled corticosteroids (ICS)/long-acting beta-agonists (LABA) at emergency department visits had lower frequencies of exacerbations compared with non-ICS/LABA-treated patients. The incidence rates for 1, 2, 3, and 4 exacerbation of the patients treated with ICS/LABA are lower than those treated without ICS/LABA (14.49 vs. 15.01%, 11.94% vs. 19.12%, 6.51% vs.12.92% and 4.10% vs. 9.35%). The difference got a statistical significance Chronic obstructive pulmonary disease (COPD) and gastroesophageal reflux disease (GERD), two comorbidities related to asthma, were risk factors for asthma exacerbation. Finally, patients who suffered from exacerbations produced a heavier economic burden compared to the patients who never suffered exacerbations (mean costs are ￥3,339.67 vs. ￥968.45 separately).  These results provide a reference for clinicians and patients to obtain a better treatment and therapy strategy management for people living with asthma. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3584 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/3584/1959