Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 22 5 2023 10 29 504 509 EN Marco Yamazaki-Nakashimada Department of Pediatric Clinical Immunology, Instituto Nacional de Pediatria. Mexico City, Mexico Patricia Herrera-Mora Department of Pediatric Neurology, Instituto Nacional de Pediatria. Mexico City, Mexico Alfonso Mahrx-Bracho Department of Pediatric Neurosurgery, Instituto Nacional de Pediatria. Mexico City, Mexico Gabriela López-Herrera Immunodeficiencies Research Unit, Instituto Nacional de Pediatria. Mexico City, Mexico Juan Bustamante-Ogando Immunodeficiencies Research Unit, Instituto Nacional de Pediatria. Mexico City, Mexico Selma Scheffler-Mendoza Department of Pediatric Clinical Immunology, Instituto Nacional de Pediatria. Mexico City, Mexico 2022 02 14 2023 05 17 Most patients with X-linked agammaglobulinemia are susceptible to infections, while some cases also suffer from inflammatory or autoimmune complications. We describe a patient with progressive encephalitis who improved after the use of immunomodulatory treatment with corticosteroids, fluoxetine, and nitazoxanide. In most of the cases the evolution of the progressive encephalitis is complicated and catastrophic. Based on our experience and the review of the literature, we propose the use of this combined treatment to control this devastating complication. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3457 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/3457/1984