Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 21 4 2022 08 12 478 483 Hossein Esmaeilzadeh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Seyed Sina Dehghani Department of Pediatric, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran Babak Shahhoseini Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Soheila Alyasin Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran Sayyed Hesamedin Nabavizadeh Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences Shiraz, Iran Aida Askari Department of Allergy and Clinical Immunology, Namazi Hospital, Shiraz University of Medical Sciences, Shiraz, Iran 2021 10 04 2022 03 06 A novel coronavirus disease known as Coronavirus Disease 2019 (COVID-19) has spread quickly throughout the world, and it was declared a pandemic in March 2022. Chronic granulomatous disease (CGD) is a diverse group of genetic disorders characterized by recurrent bacterial and fungal infections, resulting in granulomas due to the inability of phagocytes to destroy microbes. Even though it is thought that impaired neutrophil activity is a protective mechanism against severe COVID-19-induced cytokine storms and hyper-inflammatory responses, patients with CGD have normal immunity to most viruses. Here, we present two CGD patients who were hospitalized due to severe COVID-19 infections, which suggests that COVID-19 might have a different pathogenesis than other viruses. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/3374 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/3374/1868