Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 10 4 2011 12 15 299 303 EN Sonja Prcic Department of Dermatovenereology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia Jelena Tomić Department of Immunology and Allergology, Institute For Child and Youth Health Care of Vojvodina, Novi Sad, Serbia Slobodanka Petrović Department of Pulmology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia Anica Radulović Department of Dermatovenereology, Institute for Child and Youth Health Care of Vojvodina, Novi Sad, Serbia Verica Djuran Clinic of Dermatovenereologic Diseases, Clinical Centre of Vojvodina, Novi Sad, Serbia Zorica Gajinov Clinic of Dermatovenereologic Diseases, Clinical Centre of Vojvodina, Novi Sad, Serbia 2015 10 01 The hyperimmunoglobulin E  syndrome is a rare complex primary immunodeficiency characterized by high serum IgE levels, eczema, and recurrent infections. We present a case of 2-years-old girl with eczema and repeated bacterial skin and lung infections since the period of infancy. The patient also had eosinophilia, high serum levels of IgE, and cows-milk hypersensitivity. We describe the case, in order to illustrate the difficulty of establishing the diagnosis hyper-immunoglobulin E syndrome in a toddler. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/324 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/324/324