Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 10 4 2011 12 15 289 293 EN Ghasem Meighani Department of Pediatrics Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Asghar Aghamohammadi Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran Honarmand Javanbakht Department of Pediatrics Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Hassan Abolhassani Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran Sina Nikayin Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran Seyed Mehryar Jafari Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran Mehdi Ghandehari Motlagh Department of Pediatrics Dentistry, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran Ahmad Reza Shamshiri Faculty of public Health and Institute of Health Research, Tehran University of Medical Sciences, Tehran, Iran Nima Rezaei Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran AND Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 2015 10 01 Primary antibody deficiencies (PAD) are a group of immune system disorders, associated with decreased levels of secretory and protective immunoglobulins. Because of the important role of immunoglobulins in the protection  of oral cavity, patients with PADs  are more susceptible to dental caries or oral manifestations. This study was performed  to investigate the oral and dental manifestations of PADs patients. In this study, 33 patients with PADs (21 common variable immunodeficiency, 8 X- linked agammaglobulinemia and 4 hyper IgM syndrome) and 66 controls were examined; the number of decayed, missed and filled teeth (DMFT) were investigated. Aphthous  was the most frequent manifestation in PADs patients (38.7%), which wassignificantly16.7% higher than  the  controls  (p=0.03). The  patients  with  PADs  showed significantly higher presentation of other oral and dental manifestations, including herpes sores, candidiasis tonsillitis, gingivitis, calculus, enamel hypoplasia and other ulcerations. The mean DMFT scores were 6.15±3.6 and 1.93±0.4 in PADs patients and controls, respectively (p<0.001). Although the patients with common variable immunodeficiency had higher means of DMFT in comparison with other groups of PADs, this difference was not statistically significant. This study showed significantly higher frequency of oral and dental manifestations in the patients with PADs  compared to controls. Therefore, regular examination of oral cavity could be suggested in this group of immunodeficient patients. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/322 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/322/322