Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 10 4 2011 12 15 261 265 EN Saeid Abediankenari Department of Microbiology and Immunology , Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Yousef Yousefzadeh Department of Microbiology and Immunology , Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mohammad Majidi Department of Microbiology and Immunology , Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Maryam Ghasemi Department of Pathology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Mohammad Mahdi Nasehi Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran Javad Ghaffari Department of Pediatrics, Mazandaran University of Medical Sciences, Sari, Iran Reza Habibi Saravi Department of Education and Research, Mazandaran Multiple Sclerosis Society, Sari, Iran Mahmoud Abedini Department of Education and Research, Mazandaran Multiple Sclerosis Society, Sari, Iran Mitra Elyasi Department of Microbiology and Immunology , Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran 2015 10 01 Multiple  sclerosis  (MS) is  an  autoimmune  multifactorial  degenerative  disease  with detrimental affliction on central nervous system. MHC class I chain- related geneA,B(MICA and MICB) are nonclassical human leukocyte antigens that can affect on some diseases and also on transplantation. The purpose of this study was to evaluate the MICA and MICB MRNA expression in multiple sclerosis patients. In this study, we evaluated MICA and MICB MRNA expression in  the  peripheral  blood  mononuclear  cells  by  reverse  transcryptase-polymerase chain reaction(RT-PCR) in MS patients and normal controls. The results of this study showed that 32.6% of patients with progressive clinical outcome over expressed MICB genes in comparison with controls ( p=0.002). It is concluded that the high expression of MICB gene in MS patients is an important criterion of MS disease that it may be due to the interaction between MICB and its receptor on CD8+T or NK cells. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/318 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/318/318