Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 2 1 2003 03 15 31 37 R. Amin Soheila Alyasin Gh. Rahmani 2015 10 01 Theophylline, (1,3-dimethylxanthine) is widely used as a smooth muscle relaxant, myocardial stimulant and a diuretic agent. The most frequent use of theophylline is in treatment of acute and chronic asthma as a bronchodilator. To determine the effect of Theophylline on serum electrolyte and uric acid, 21 asthmatic children (age range 1,5-7 years) with severe acute asthma and 25 patients with chronic asthma (5-15 years ) who were being treated with slow-release theophylline were enrolled in this study. Fifty age and sex matched normal children took part as control. Blood samples (5ml) were withdrawn before, during and after completion of the course of intravenous theophylline treatment (0.05-0.70 mg/kg/ hr). Sera obtained were used for analysis of K+, Na+, phosphorus, calcium and uric acid by RA-1000 automated analyzer and the following results were obtained: (1) After treatment, total serum calcium in acute asthmatic patients decreased significantly compared with controls (P https://ijaai.tums.ac.ir/index.php/ijaai/article/view/31 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/31/31