Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 10 2 2011 06 15 133 137 EN Sara Kashef Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AND Department of Pediatric Immunology and Allergy, Shiraz University of Medical Sciences, Shiraz, Iran Mozhgan Moghtaderi Allergy Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Mohammad Borzouee Department of Pediatric Cardiology, Shiraz University of Medical Sciences, Shiraz, Iran Nima Rezaei Molecular Immunology Research Center; and Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran AND Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran 2015 10 01 Common variable immunodeficiency (CVID) is the most common symptomatic primary immunodeficiency disease, predisposing the patients to various tissue involvement and organ damage. Here a 16-year-old boy is presented who was referred to our center with cough, dyspnea,cyanosis, and history of recurrent pneumonia. The diagnosis of CVID was made according to reduction all serum immunoglobulin levels, normal numbers of T, B and NK lymphocyte subpopulations, poor antibodies responses. Considering abnormality in heart examination and chest X-ray, echocardiography and computed tomography angiography were performed which showed large thoraco-abdominal aortic aneurysm in this patient. Although there are some reports of cardiovascular disease associated with primary antibody deficiencies, this is the first time that such large thoraco-abdominal aortic aneurysm is reported  in CVID.  This may  be secondary  to recurrent  pulmonary infections  or  an unknown mutation process. Cardiovascular abnormalities are an entity that should be kept in mind in patients with primary immunodeficiency diseases. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/303 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/303/303