Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 2 1 2003 03 15 13 15 A. Farhoiidi A. Siadati Lida Atarod P. Tabatabae Setareh Mamishi Gh. Khotaii Sh. Arntin F. Shirvani 2015 10 01 Chronic granulomatous disease is an infrequent primary immunodeficiency characterized by defective intracellular killing of ingested microorganisms thereby making patients highly susceptible to recurrent lite threatening bacterial and fungal infections. In this study, we review the medical course of an 8 yr old girl with AR-CGD. She suffered from recurrent dermal and deep abscesses, retractable salmonellosis, disseminated BCGosis, recurrent aspergillus infection presenting as mandibular osteomyelitis and pulmonary involvement with invasion to rib and vertebral bodies. Despite of longterm IV amphotricin B, itraconazole and IFN-y administration, and surgical interventions (drainage and resection), she died in spite of long term antibiotic anti fungal prophylaxis and interferon-gamma administrations, invasive aspergillosis resistant to current conventional therapies is the cause of 1/2 to 1/3 of CGD deaths. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/28 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/28/28