Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 19 4 2020 08 25 447 451 Saba Arshi Department of Allergy and Clinical Immunology, Rasoul-E-Akram Hospital, Iran University of Medical Science, Tehran, Iran Narges Eslami Department of Allergy and Clinical Immunology, Mofid Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Mohammad Nabavi Department of Allergy and Clinical Immunology, Rasoul-E-Akram Hospital, Iran University of Medical Science, Tehran, Iran Mohammad Bemanian Department of Allergy and Clinical Immunology, Rasoul-E-Akram Hospital, Iran University of Medical Science, Tehran, Iran Morteza Fallahpour Department of Allergy and Clinical Immunology, Rasoul-E-Akram Hospital, Iran University of Medical Science, Tehran, Iran Sima Shokri Department of Allergy and Clinical Immunology, Rasoul-E-Akram Hospital, Iran University of Medical Science, Tehran, Iran Javad Ahmadian Department of Pediatric, Emam Reza Hospital, Tabriz University of Medical Sciences, Tabriz, Iran Rasool Molatefi Department of Pediatrics, Bu Ali Hospital, Ardebil University of Medical Sciences, Ardebil, Iran Kyan Darabi Iran Allergy Clinics, Tehran, Iran Golam Reza Sedighi Department of Pediatric, Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran Zeinab Moinfar Department of Community Medicine, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran Sepideh Darougar Department of Pediatrics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran 2020 03 10 2020 06 22 Asthma induced by ingestion of aspirin occurs when symptoms arise within 30 minutes to three hours after aspirin consumption. Previous data indicate that sensitivity to aspirin may be associated with poorly controlled asthma. This study aims to evaluate the frequency of aspirin sensitivity in patients with moderate to severe asthma receiving conventional asthma therapy. This clinical trial was conducted on 65 patients aged 18 to 65 years with moderate to severe asthma from February 2015 to February 2016 at the Allergy Department, Hazrat-e-Rasoul Hospital, Iran University of Medical Sciences, Tehran. To assess treatment responses in patients, forced expiratory volume in the first second (FEV1) and asthma control test (ACT) scores were measured at baseline and after 3 months. The results of the oral aspirin challenge revealed a prevalence of 35.38% for sensitivity to aspirin. Hypersensitivity reactions to aspirin were detected in 60.9% of the patients with moderate asthma and 39.1% of the patients with severe asthma. All patients with positive aspirin challenge tests suffered from rhinosinusitis and in 56.5% of cases, history of previous hypersensitivity reactions to non-steroidal anti-inflammatory drugs (NSAIDs) was detected. No meaningful differences were found between those patients with aspirin sensitivity and those with aspirin tolerance neither in mean pre-bronchodilator FEV1 nor in ACT scores pre- and post-treatment. To conclude, aspirin sensitivity was not found to have an association with an unfavorable response to conventional treatment in patients with uncontrolled asthma.  https://ijaai.tums.ac.ir/index.php/ijaai/article/view/2741