Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 9 2 2010 06 15 97 102 Ibtissam Ouahidi Laboratory of Bioactive Molecules (LMBSF), Faculty of Sciences & Technology, Fez, Morocco Amal El Youbi Elhamsas Laboratory of Bioactive Molecules (LMBSF), Faculty of Sciences & Technology, Fez, Morocco Youssef Bouyahyaoui Department of dermatology, Hospital University Center of Fez, Morocco Fatima Zahra Mernissi Department of dermatology, Hospital University Center of Fez, Morocco Lotfi Aarab Laboratory of Bioactive Molecules (LMBSF), Faculty of Sciences & Technology, Fez, Morocco 2015 10 01 The aim of the present study was to characterize allergen-specific immunoglobulin E (IgE) among children in Fez region. Eighty one children were recruited from the Hospital University Center of Fez. All of them had completed a questionnaire before taking sera. The sera were used to measure total IgE and specific data to proteins of egg's white (EWP), peanuts (PP) and gliadins (G). In last part, we studied the reactivity of specific IgE to native and to heat- and acid-treated allergens. Allergen-specific IgE measurement indicated more positive values for gliadins (46.9% up to 2IU/ml) than egg white's (29.6%) and peanut's proteins (22.2%). According to predictive values published by Sampson (2001), 14.3% of children are sensitive to egg white's proteins, 4.1% to gliadins and 2.7% to peanut's proteins. The allergenic potential of EWP and gliadins among children were partially diminished by heat and acid treatment. Allergen-specific IgE measurement indicates that children from Fez region are more sensitive to EWP than peanut's proteins and gliadins. Treatments of these food proteins indicated that recognition by children IgE can be reduced by thermal or acid treatment of these allergens. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/274 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/274/274