Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 8 4 2009 12 15 215 218 Soheila Moradi Mofid Children Hospital, Shaheed Beheshti University, Tehran, Iran Zahra Chavoshzadeh Pediatric Infections Research Center, Shaheed Beheshti University, Tehran, Iran Mina Izadyar Department of Pediatrics, Pediatrics Center of Excellence, Children's Medical Center, Tehran Univers Fatemeh Mahjoub Division of Pathology, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Ira Nima Rezaei Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran 2015 10 01 Idiopathic CD4+ Lymphocytopenia is a rare combined immunodeficiency disease, characterized by low CD4+ T-cell count and increased susceptibility to opportunistic infections, autoimmunity and malignancies after exclusion of secondary forms of CD4 lymphocytopenia. Here we present a 13-year old boy who was referred to our center because of destructive ulceration of soft and hard palates with extension to nose and maxillary sinus starting at 6 months of age. He had a history of recurrent otitis media, chronic diarrhea, arthritis and herpetic lesions of eyes and mouth since the age of 5 years. Laboratory studies revealed very low number of CD4+ T-cells ( https://ijaai.tums.ac.ir/index.php/ijaai/article/view/260 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/260/260