Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 8 3 2009 09 15 149 154 Mahir Igde Department of Pediatric Allergic Diseases, Maternity and Children Hospital, Samsun, Turkey Fusun Artiran Igde Department of Family Medicine, School of Medicine, Ondokuz Mayis University, Samsun, Turkey Zafer Yazici Department of Virology, Faculty of Veterinary Medicine, Ondokuz Mayis University, Samsun, Turkey 2015 10 01 This study investigated the association between HSV-1 infection and atopy by comparing seropositivity to HSV-1 in atopic children with asthma and allergic rhinitis and in non-atopic children. Totally 249 children randomly selected from the university outpatient pediatric clinics were prospectively enrolled in the study between September 1 and November 30, 2007. Serum samples were examined using the virus neutralization test (VNT) for HSV-1 Immunoglobulin G(IgG) seropositivity. Skin prick tests (SPTs) were performed to determine atopic status. The results showed that HSV-1 IgG seropositivity was significantly higher in atopic children (56.8%) with asthma and allergic rhinitis than in the age-matched non-atopic children group (30.4%) (p https://ijaai.tums.ac.ir/index.php/ijaai/article/view/249 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/249/249