Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 8 3 2009 09 15 141 147 Wen-Liang Fang Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University Lin-Bo Gao Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan Univ Wei-Bo Liang Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan Univ Hui Xue Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University Peng Bai Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan Univ Mei-Li Lv Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University Yan-Yun Wang Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University Bin Zhou Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan Unive Lin Zhang Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University 2015 10 01 Several asthma susceptibility loci, including a region containing the vitamin D receptor (VDR) gene located at chromosome 12q, have been identified using genome-wide screens. Our aim is to investigate the association between single nucleotide polymorphisms (SNPs) in VDR gene and asthma. One hundred one asthma patients and 206 healthy controls were enrolled in this study. Genotypes were determined using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy and DNA sequencing. The results showed that there was no significant differences in the genotype and allele frequencies of Fok I and Bsm I polymorphisms between asthma patients and the controls in the Chinese Hans (For Fok I: OR = 1.15, 95% CI: 0.82-1.60; for Bsm I: OR = 1.44, 95% CI: 0.87-2.38). It is suggested that Fok I and Bsm I polymorphisms of VDR gene may not significantly contribute to the development of asthma in the Chinese Hans. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/248 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/248/248