Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 8 1 2009 03 15 49 52 Agache Ioana Transylvania University, Faculty of Medicine, Department of Allergy and Clinical Immunology, Romania Duca Liliana Transylvania University, Faculty of Medicine, Department of Allergy and Clinical Immunology, Romania Anghel Mariana Brasov County Hospital, Immunology Laboratory, Romania Pamfil Gheorghe Transylvania University, Faculty of Medicine, Department of Biostatistics, Romania 2015 10 01 Several studies reported the appearance of asthma and autoimmune conditions in the same patient, but the clinical significance of this association was not yet assessed. One hundred asthmatic patients were observed for one year evolution with death, severe exacerbations, intake of > 1000 micrograms of beclometasone or equivalent (high ICS) and FEV1 decline >100 ml, in relation with ANA (ELISA), sputum and blood eosinophilia (EO), NSAID intolerance, BMI >25, chronic rhinosinusitis, smoking status and FEV1 100 ml/year). Multiple regression analysis pointed out several different independent risk factors for severe asthma evolution: for death presence of ANA (P=0.037), NSAID intolerance (P25 (P=0.046) and NSAID intolerance (P=0.017) The presence of ANA is an independent risk factor in asthma for evolution with death, severe exacerbations, high inhaled corticosteroid intake and FEV1 decline >100 ml. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/233 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/233/233