Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 8 1 2009 03 15 43 47 Aghamohammadi Asghar Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Cheraghi Taher Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran Rezaei Nima Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, I Kanegane Hirokazu Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama, Japan Abdollahzede Sina Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran Talaei-Khoei Mojtaba Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran Heidari Golnaz Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran Zandieh Fariborz Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Moin Mostafa Department of Pediatrics, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Miyawaki Toshio Department of Pediatrics, Graduate School of Medicine, University of Toyama, Toyama, Japan 2015 10 01 X-linked Agammaglobulinemia (XLA) is a hereditary immunodeficiency, characterized by an early onset of recurrent bacterial infections, hypogammaglobulinemia and markedly reduced B lymphocytes number. In order to determine the association of neutropenia among Iranian patients with XLA, hospital records of 30 patients with confirmed XLA in Children Medical Center Hospital, were reviewed. Eight out of 30 XLA patients (26.7%) developed neutropenia during the course of the disease. In two patients, episodes of neutropenia were identified before or at the time of diagnosis of XLA. Other six patients whom were not visited regularly and did not receive periodical immunoglobulin replacement therapy experienced neutropenia after diagnosis of XLA. Neutropenia in XLA is mainly associated with infection and is resolved with intravenous immunoglobulin replacement and antibiotics therapy. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/232 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/232/232