Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 7 4 2008 12 15 231 234 Rezaei Nima Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Ir Aghamohammadi Asghar Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Ir Read Robert C. Section of Infection, Inflammation and Immunity, School of Medicine and Biomedical Sciences, 2015 10 01 Common variable immunodeficiency (CVID) is a heterogeneous group of disorders, characterized by hypogammaglobulinemia and increased susceptibility to recurrent infections, autoimmunity and malignancies. We have previously shown that some pediatric patients with CVID can respond to meningococcal polysaccharide vaccine. Twelve pediatric cases with CVID were re-evaluated to determine whether bactericidal antibody responses or IgM memory B-cells correlate with the severity of disease resulting from the deficiency. We found that bronchiectasis and clinical manifestations of autoimmunity occur more commonly amongst non-responders to vaccine. In contrast, low populations of memory B-cells do not correlate with these sequelae. The results of this study could help pediatricians plan strategies for prevention of sequelae in children presenting with CVID. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/224 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/224/224