Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 18 1 2019 02 24 12 26 EN Farzaneh Shakeri Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran Vahideh Ghorani Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Saeideh Saadat Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Zahra Gholamnezhad Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran Mohammad Hossein Boskabady Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran 2017 12 28 2018 05 09 Medicinal plants have been identified and used as primary sources in prevention and treatment of pulmonary diseases (mainly obstructive pulmonary diseases) from ancient times due to various pharmacological activities. In this review, the stimulatory effects of extracts, some fractions and constituents of medicinal plants on β2-adrenoceptors which could be used as possible therapeutic agents in the future were reviewed. Various databases including; Medline, PubMed, ScienceDirect, Scopus, and Google Scholar were searched using stimulatory effect, β2-adrenoceptors, possible mechanism, tracheal smooth muscle (TSM), medicinal plants and their constituents as keywords from 1985 to 2017. All studied plants including; Nigella sativa, Rosa damascena, Thymus vulgaris, Carum copticom, Carum carvi, Zataria multiflora, Crocus sativus, Cuminum cyminum, Liomnia acidissima, Portulaca oleraceae, Satureja hortensis, Ephedra sinica and Achillea millefolium showed relaxant effect on tracheal smooth muscle with a stimulatory effect on β2-adrenoceptors mechanism. The studied plants and their constituents could be of therapeutic value in clinical practice as a bronchodilatory drug by β2-adrenoceptors stimulatory mechanism for treatment of obstructive pulmonary diseases. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1803 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1803/1378