Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 17 6 2018 12 01 502 516 EN Shikun Ma Department of Allergy, Peking Union Medical College Hospital, Chineses Academy of Medical Sciences and Peking Union Medical College, Beijing, China Jian Guan Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China 2017 10 12 2018 05 21 Allergy poses a heavy health burden in modern society. Other than symptom-relieving medications, the only available treatment approach is allergen-specific immunotherapy, which in spite of offering a potential cure, requires a long treatment duration with multiple doses of allergen administration and carries a risk of anaphylaxis. Gene therapy has shown advantages in experimental studies for treatment of tumors, genetic diseases, chronic infections, and allergy. To date, adenovirus has been the most extensively used gene transfer vector, and offers high efficiency and safety. Here, we review studies of adenovirus-mediated gene therapy targeting different steps in the development of allergic diseases. Adenovirus-mediated gene therapy might be a promising add-on therapy for allergy treatment. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1685 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1685/1372