Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 17 3 2018 06 10 291 294 EN Ioana Muntean Department of Immunology and Allergology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania Ioana Bocsan Department of Pharmacology, Toxicology and Clinical Pharmacology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania Diana Deleanu Department of Immunology and Allergology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj Napoca, Romania 2017 07 31 2017 09 25 Wheat is the most commonly grown cereal. Immunological reaction to wheat may be IgE or T-cell- mediated. Asthma could be induced by inhaled flour or by exposure to allergens present in bakery products. In patients with IgE-mediated allergy to wheat proteins there is no specific therapy, except oral immunotherapy (OIT). There are few data regarding OIT with wheat protein in allergic patients. We present a case of a 32-yearold female patient, who worked for 5 years in wheat and bakery products industry, who developed an occupational asthma and chronic urticaria after flour inhalation or ingestion of foods that containit. The patient underwent wheat  OIT, that  was well-tolerated with no severe reaction during treatment. We may conclude that wheat OIT is a safe therapy and may induce symptoms improvement in allergic asthma and urticaria in patients with wheat allergy. Wheat OIT may induce tolerance to allergic patients. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1588 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1588/834