Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 16 3 2017 06 17 198 204 EN Saeideh Mazloomzadeh Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Niousha Bakhshi Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran Akefeh Ahmadiafshar Social Determinants of Health Research Center, Zanjan University of Medical Sciences, Zanjan, Iran AND Mousavi Hospital, Zanjan University of Medical Sciences, Zanjan, Iran AND Metabolic Diseases Research Center, Zanjan University of Medical Sciences, Zanjan, Iran Mehdi Gholami Zanjan Cultural Heritage Department, Zanjan, Iran 2016 09 28 2017 01 31 The asthma treatment and control might be associated with significant burden on family and community‚ thus exploring other therapeutic plans could be desirable. The aim of this study was to investigate the effect of salt space on clinical findings and peak expiratory flow rate among children with asthma. In this randomized crossover trial, 34 patients aged 6-14 years old with mild to moderate asthma were selected and randomly divided into two groups. The first group went through a period of salt therapy by staying in the salt room for one hour, three times a week for 3 consecutive weeks and then was under observation for three weeks. This process was reversed for the second group (three weeks under observation followed by salt therapy). The wash-out period was one week. During the study, the morning and evening peak expiratory flow (PEF), the frequency of coughing, wheezing, dyspnea and use of rescue medications were measured. Salt therapy had a significant effect on raising the morning and evening PEF in the second week in both groups (p=0.028 and p=0.032, respectively). However, there was no significant effect on PEF variabilities‚ cough‚ wheezing, dyspnea, and the frequency of rescue medication (p>0.05). No side effect was observed during salt therapy. This study showed the significant effect of salt therapy on PEF rate of the patients in the second week. However, further studies with different frequency and time of salt therapy on respiratory disorders are recommended.  https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1079 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1079/739