Tehran University of Medical Sciences Iranian Journal of Allergy, Asthma and Immunology 1735-1502 17 1 2018 02 26 97 99 EN Selçuk Yazıcı Department of Pediatrics, Medical Faculty, Balıkesir University, Balıkesir, Turkey Hikmet Nacaroglu Department of Pediatrics, Behçet Uz Children Hospital, İzmir, Turkey Semiha Bahçeci Erdem Department of Pediatrics, Behçet Uz Children Hospital, İzmir, Turkey Sait Karaman Department of Pediatrics, Behçet Uz Children Hospital, İzmir, Turkey Demet Can Division of Pediatric Allergy, Department of Pediatrics, Medical Faculty, Balıkesir University, Balıkesir, Turkey 2016 08 02 2017 06 03 We present a 13-year-old male childallergic to three different plants (Salvia officinalis, Mentha piperita and Origanum onites L.) of Lamiaceae family. The patient developed angioedema 20-30 minutes after eating chicken meat with cheddar cheese. There was no history of allergy. Oral food challenge (OFC) with both cheddar cheese and chicken meat was negative. Skin tests for inhalant allergens were negative. 3 weeks later, the patient was admitted with angioedema after drinking sage tea. OFC with sage was applied and angioedema was observed. It was recognized that the first trigger, chicken meat with cheddar cheese, included oregano (Origanum onites L.). OFC for oregano was positive. Prick to prick test for Lamiaceae herbs (oregano, sage, mint) was performed. A positive reaction was observed only to mint. OFC was repeated with fresh mint and angioedema developed after 16 hours. Diagnose of Lamiaceae allergy is complicated and cross-sensitivity is common. Skin prick test (prick to prick)revealed a positive response only to mint but not to oregano and sage. Commercial radioallergosorbent (RAST) tests are available only for a few members of the family. Finally, thediagnose is based mainly on OFC. Spices from Lamiaceae group should be considered as potential triggers of allergic reactions. https://ijaai.tums.ac.ir/index.php/ijaai/article/view/1023 https://ijaai.tums.ac.ir/index.php/ijaai/article/download/1023/809