Endobronchial Lesion in Eosinophilic Granulomatosis with Polyangiitis

  • Guan-Liang Chen Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan AND Division of Chest Medicine and Respiratory Therapy, Department of Internal Medicine, Taichung Armed Forces General Hospital, Taichung, Taiwan
  • Chun-Han Wu Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
  • Wann-Cherng Perng Division of Pulmonary and Critical Care, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
Keywords: Bronchoscopy, Eosinophilic granulomatosis with polyangiitis, Vasculitis

Abstract

Eosinophilic granulomatosis with polyangiitis is a systemic vasculitis. It could affect respiratory system, kidney, and central nervous system frequently; however, all body organs could be involved. Asthma and eosinophilic pneumonia are predominant manifestations in respiratory system. Bronchoalveolar lavage or lung biopsy may be used for diagnosis, but endobronchial lesion is not considered as a manifestation of eosinophilic granulomatosis with polyangiitis. Here we present a case of eosinophilic granulomatosis with polyangiitis with unusual endobronchial lesion which was confirmed by endobronchial biopsy.

References

Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol 1951; 27(2):277-301.Guillevin L, Cohen P, Gayraud M, Lhote F, Jarrousse B, Casassus P. Churg-Strauss syndrome. Clinical study and long-term follow-up of 96 patients. Medicine (Baltimore) 1999; 78(1):26-37.Pagnoux C, Guilpain P, Guillevin L. Churg-Strauss syndrome. Curr Opin Rheumatol 2007; 19(1):25-32.Allen JN, Davis WB. Eosinophilic lung diseases. Am J Respir Crit Care Med 1994; 150(5 Pt 1):1423-38.Gioffredi A, Maritati F, Oliva E, Buzio C. Eosinophilic granulomatosis with polyangiitis: an overview. Front Immunol 2014; 5:549.Sablé-Fourtassou R, Cohen P, Mahr A, Pagnoux C, Mouthon L, Jayne D, et al. Antineutrophil cytoplasmic antibodies and the Churg-Strauss syndrome. Ann Intern Med 2005; 143(9):632–8.Sinico RA, Di Toma L, Maggiore U, Bottero P, Radice A, Tosoni C, et al. Prevalence and clinical significance of antineutrophil cytoplasmic antibodies in Churg-Strauss syndrome. Arthritis Rheum 2005; 52(9):2926–35.Hara Y, Kanoh S, Shinkai M, Kawana A. Churg-Strauss syndrome with endobronchial eosinophilic vasculitis. Intern Med 2012; 51(22):3227.Alvarez-Sala R, Prados C, Armada E, et al. Congestive cardiomyopathy and endobronchial granulomas as manifestations of Churg-Strauss syndrome. Postgrad Med J 1995; 71(836):365-6.Rajendra Prasad. (2013). Atlas of fiberoptic bronchoscopy. New Delhi, India: Jaypee Brothers Medical Publishers.Cho BH, Oh Y, Kang ES. Aspergillus tracheobronchitis in a mild immunocompromised host. Tuberc Respir Dis (Seoul) 2014; 77(5):223-6.

Published
2017-12-23
How to Cite
1.
Chen G-L, Wu C-H, Perng W-C. Endobronchial Lesion in Eosinophilic Granulomatosis with Polyangiitis. ijaai. 16(6):561-4.
Section
Case Report(s)