Iranian Journal of Allergy, Asthma and Immunology 2016. 15(3):198-203.

Sensitization to Food Additives in Patients with Allergy: A Study Based on Skin Test and Open Oral Challenge
Mozhgan Moghtaderi, Zinatosadat Hejrati, Zahra Dehghani, Faranak Dehghani, Niloofar Kolahi

Abstract


There has been a great increase in the consumption of various food additives in recent years. The purpose of this study was to identify the incidence of sensitization to food additives by using skin prick test in patients with allergy and to determine the concordance rate between positive skin tests and oral challenge in hypersensitivity to additives. This cross-sectional study included 125 (female 71, male 54) patients aged 2-76 years with allergy and 100 healthy individuals. Skin tests were performed in both patient and control groups with 25 fresh food additives. Among patients with allergy, 22.4% showed positive skin test at least to one of the applied materials. Skin test was negative to all tested food additives in control group. Oral food challenge was done in 28 patients with positive skin test, in whom 9 patients showed reaction to culprit (Concordance rate=32.1%). The present study suggested that about one-third of allergic patients with positive reaction to food additives showed positive oral challenge; it may be considered the potential utility of skin test to identify the role of food additives in patients with allergy.


Keywords


Allergy; Food additives; Skin test

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References


1.   World Health Organization. Evaluation of certain food additives and  contaminants. World  Health  Organ  Tech Rep Ser 2013; (983):1-75.

2.   Wilson   BG,   Bahna   SL.   Adverse   reactions  to   food additives.    Ann    Allergy    Asthma    Immunol   2005;95(6):499-507.

3.   Simon RA. Adverse reactions to food additives. N Engl Reg Allergy Proc. 1986 Nov-Dec; 7(6):533-42.

4.   Simon  RA.  Adverse  reactions  to  food  additives.  Curr Allergy Asthma Rep 2003; 3(1):62-6.

5.   Connolly A, Hearty A, Nugent A, McKevitt A, Boylan E, Flynn A, et al. Pattern of intake of food additives associated with hyperactivity in Irish children and teenagers. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 2010; 27(4):447-56.

6.   Freedman  BJ.   Asthma  induced   by  sulphur  dioxide, benzoate and tartrazine contained in orange drinks. Clin Allergy 1977; 7(5):407-15.

7.   Papanikolaou I, Stenger R, Bessot JC, de Blay F, Pauli G. Anaphylactic shock to  guar  gum (food  additive  E412) contained in a meal substitute. Allergy 2007; 62(7):822.

8.   Madsen C. Prevalence of food additive intolerance. Hum  Exp Toxicol 1994; 13(6):393-9.

9.   Randhawa  S,  Bahna  SL.  Hypersensitivity  reactions  to food additives. Curr Opin Allergy Clin Immunol 2009;9(3):278-83.

10. Chiriac AM, Bousquet J, Demoly P. In vivo methods for the study and diagnosis of allergy. In: Adkinson N.F, S. Bochner B, Burks A.W, W.Busse W, T. Holgate Stephen,editors. Middleton’s  Allergy Principles and Practice. 8th ed. Philadelphia: Saunders  Elsevier; 2013. 1119-29.

11. Park HW, Park CH, Park SH, Park JY, Park HS, Yang HJ, et al. Dermatologic adverse reactions to 7 common food additives in patients with allergic diseases: a double- blind, placebo-controlled study. J Allergy Clin Immunol 2008; 121(4):1059-61.

12. Malanin G, Kalimo K. The results of skin testing with food additives and the effect of an elimination diet in chronic and recurrent urticaria and recurrent angioedema. Clin Exp Allergy 1989; 19(5):539-43.

13. Bock SA, Sampson HA, Atkins FM, Zeiger RS, Lehrer S, Sachs M, et al. Double-blind, placebo-controlled food challenge (DBPCFC) as an office procedure: a manual. J Allergy Clin Immunol 1988; 82(6):986-97.

14. Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bachert C, Canonica GW, et al. MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): The new generation   guideline   implementation.   Allergy   2015;70(11):1372-92.

15.   Bateman ED, Hurd SS, Barnes PJ, Bousquet J, Drazen JM, FitzGerald M, et al.   Global strategy for asthma management and prevention: GINA executive summary. Eur Respir J. 2008 Jan;31(1):143-78.

16. Park HW, Park CH, Park SH, Park JY, Park HS, Yang HJ, et al. Dermatologic adverse reactions to 7 common food additives in patients with allergic diseases: a double- blind, placebo-controlled study. J Allergy Clin Immunol 2008; 121(4):1059-61.

17. Rajan JP, Simon RA, Bosso JV. Prevalence of sensitivity to food and drug additives in patients with chronic idiopathic urticaria. J Allergy Clin Immunol Pract 2014;2(2):168-71.

18. Wüthrich B. Adverse reactions to  food  additives.  Ann Allergy 1993; 71(4):379-84.

19. Taylor SL, Dormedy ES. The role of flavoring substances in food allergy and intolerance. Adv Food Nutr Res 1998;42:1-44.

20. Shirao K, Inoue M, Tokuda R, Nagao M, Yamaguchi M, Okahata H, et al. "Bitter sweet": a child case of erythritol- induced anaphylaxis. Allergol Int 2013; 62(2):269-71.

21. Hawkins  CA,  Katelaris  CH.  Nitrate  anaphylaxis.  Ann  Allergy Asthma Immunol 2000; 85(1):74-6.

22.   Soodam  K,  Ong  L,  Powell  IB,  Kentish  SE,  Gras  SL.Effect of calcium chloride addition and draining pH on the microstructure and texture of full fat Cheddar cheese during ripening. Food Chem. 2015 Aug 15;181:111-8.

23. Lee HJ, Anderson Z, Ryu D. Gluten contamination in foods labeled as "gluten free" in the United States. JProt 2014; 77(10):1830-324.

24. La  Vieille  S,  Dubois  S,  Hayward  S,  Koerner  TB.Estimated  levels  of  gluten  Canadian gluten-free diet. Nutrients 2014; 6(2):881-96  .

25. Di  Lorenzo  G,  Pacor  ML,  Mansueto  P,  Martinelli  N, Esposito-Pellitteri M, Lo Bianco C, Ditta V, Leto-Barone MS, Napoli N, Di Fede G, Rini G, Corrocher R. Food- additive-induced urticaria: a survey of 838 patients with recurrent chronic idiopathic urticaria.  Int Arch  Allergy Immunol 2005; 138(3):235-42.

26. Jansen JJ, Kardinaal AF, Huijbers G, Vlieg-Boerstra BJ, Martens BP, Ockhuizen T. Prevalence of food allergy and intolerance in the adult Dutch population. J Allergy Clin Immunol 1994; 93(2):446-56.

27. Fuglsang   G,   Madsen   G,   Halken   S,   Jørgensen   S, Ostergaard PA, Osterballe O. Adverse reactions to food additives  in  children  with  atopic  symptoms.  Allergy 1994; 49(1):31-7.

28. Hannuksela M, Haahtela T. Hypersensitivity reactions to food additives. Allergy 1987; 42(8):561-75.


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