Epigenetics and Behçet’s Disease: DNA Methylation Specially Highlighted

  • Jafar Farhadi Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran AND Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Mohammad Nouri Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Ebrahim Sakhinia Department of Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Nasser Samadi Department of Biochemistry, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Zohreh Babaloo Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  • Shahriar Alipour Department of Biochemistry, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran
  • Golamreza Jadideslam Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran AND Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran AND Tuberculosis and Lung Disease Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
  • Farhad Pouremamali Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
  • Alireza Khabbazi Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords: Behcet’s disease, DNA methylation, Epigenetics

Abstract

Behçet's disease (BD) is a multisystem inflammatory disease with unknown etiology. Although evidence about the pathogenesis of BD is growing, the actual cause of this disease is unclear. Both genetic and epigenetic factors are claimed to play significant roles in BD. Epigenetic factors such as age, gender, smoking as well as exogenous factors like diet, infection, stress are related to the onset and clinical manifestations of BD. DNA methylation refers to a major epigenetic element which influences gene activities with catalyzing DNA using a set of DNA methyltransferases (Dnmts). DNA methylation status of many genes in patients with BD is different from that of healthy people. For example, cytoskeletal gene, Human Leukocyte Antigen (HLA) loci, Long interspersed nuclear element (LINE-1), and Arthrobacter luteus (Alu) repetitive sequences are different in the DNA methylation status in patients with BD and healthy controls. In this paper we reviewed, according to previous studies, the mechanisms of epigenetic, the epigenetic factors involved in the BD, and especially the effect of DNA methylation in the Behcet’s disease. Future studies are needed to identify the capability of specific DNA methylation alterations in BD in order to predict disease manifestations, medical course, and response to treatment.

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Published
2019-10-23
How to Cite
1.
Farhadi J, Nouri M, Sakhinia E, Samadi N, Babaloo Z, Alipour S, Jadideslam G, Pouremamali F, Khabbazi A. Epigenetics and Behçet’s Disease: DNA Methylation Specially Highlighted. Iran J Allergy Asthma Immunol. 18(5):462-472.
Section
Review Article(s)