The Stimulatory Effects of Medicinal Plants on β2-adrenoceptors of Tracheal Smooth Muscle

  • Farzaneh Shakeri Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
  • Vahideh Ghorani Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Saeideh Saadat Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Zahra Gholamnezhad Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Hossein Boskabady Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran AND Neurogenic Inflammation Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Keywords: β2-adrenoceptors, Medicinal plant, Possible mechanism, Stimulatory effect, Tracheal smooth muscle

Abstract

Medicinal plants have been identified and used as primary sources in prevention and treatment of pulmonary diseases (mainly obstructive pulmonary diseases) from ancient times due to various pharmacological activities. In this review, the stimulatory effects of extracts, some fractions and constituents of medicinal plants on β2-adrenoceptors which could be used as possible therapeutic agents in the future were reviewed. Various databases including; Medline, PubMed, ScienceDirect, Scopus, and Google Scholar were searched using stimulatory effect, β2-adrenoceptors, possible mechanism, tracheal smooth muscle (TSM), medicinal plants and their constituents as keywords from 1985 to 2017. All studied plants including; Nigella sativa, Rosa damascena, Thymus vulgaris, Carum copticom, Carum carvi, Zataria multiflora, Crocus sativus, Cuminum cyminum, Liomnia acidissima, Portulaca oleraceae, Satureja hortensis, Ephedra sinica and Achillea millefolium showed relaxant effect on tracheal smooth muscle with a stimulatory effect on β2-adrenoceptors mechanism. The studied plants and their constituents could be of therapeutic value in clinical practice as a bronchodilatory drug by β2-adrenoceptors stimulatory mechanism for treatment of obstructive pulmonary diseases.

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Published
2019-02-24
How to Cite
1.
Shakeri F, Ghorani V, Saadat S, Gholamnezhad Z, Boskabady MH. The Stimulatory Effects of Medicinal Plants on β2-adrenoceptors of Tracheal Smooth Muscle. Iran J Allergy Asthma Immunol. 18(1):12-26.
Section
Review Article(s)