Iranian Journal of Allergy, Asthma and Immunology 2017. 16(4):298-306.

Determination of the Most Common Indoor and Outdoor Allergens in 602 Patients with Allergic Symptoms Using Specific IgE Local Panel
Raheleh Shokouhi Shoormasti, Zahra Pourpak, Mohammad Reza Fazlollahi, Azadeh Shabani, Anoshirvan Kazemnejad, Zahra Ebadi, Behnoosh Tayebi, Behzad Darabi, Masoud Movahedi, Seyed Alireza Mahdaviani, Mostafa Moin

Abstract


Aeroallergens play an important role in developing allergic diseases. The aim of this study was to determine the outdoor and indoor sensitization using a specific regional panel of aeroallergens in allergic patients. All patients with allergic symptoms referred to Immunology, Asthma and Allergy Research Institute (IAARI) in Tehran, Iran from December 2010 to July 2013 entered this cross sectional study. We evaluated serum samples for specific IgE against 20 selected aeroallergens provided by a specific panel (RIDA Allergy Screen test, IAARI panel). A p value less than 0.05 was considered as significant. The patients (n=602) were 49.8 % male and 50.2% female. The median age was 9 years. Positive specific IgE at least to one allergen was 53.2%. The percentages of patients with only outdoor or indoor sensitization were 37.5 and 19.7%, respectively. Moreover, 42.8% showed sensitization to both indoor and outdoor aeroallergens. The most common outdoor aeroallergens in decreasing order were plane tree (32.8%), Bermuda grass (32.2%), timothy grass (30.6%), saltwort (28.4%). The percentage of specific IgE to indoor allergens including mold and mite were 23.8 % and 22.2%, respectively. There was a statistically significant relationship between specific IgE to timothy grass and mold allergens between two genders (p=0.04 and p=0.02, respectively).The results of this study shows that outdoor aeroallergens can be considered as the most common causes of allergic symptoms in our allergic patients.


Keywords


Aeroallergens; Epidemiology; IgE-mediated hypersensitivities; Specific IgE; Sensitization

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References:

 

1.         Lotvall J, Pawankar R, Wallace DV, Akdis CA, Rosenwasser LJ, Weber RW, et al. We call for iCAALL: International Collaboration in Asthma, Allergy and Immunology. Allergy 2012;67(4):449-50.

2.         Pawankar R, Canonica GW, Holgate ST, Lockey RF. Allergic diseases and asthma: a major global health concern. Curr Opin Allergy Clin Immunol 2012;12(1):39-41.

3.         Mari A, Rasi C, Palazzo P, Scala E. Allergen databases: current status and perspectives. Curr Allergy Asthma Rep 2009;9(5):376-83.

4.         Żukiewicz-Sobczak W, Krasowska E, Zwoliński J, Sobczak P, Chmielewska-Badora J, Wróblewska P, et al. Allergic diseases–current state of knowledge. Postep Derm Alergol 2012;29:451-5.

5.         Pinto JM NR. Allergic Rhinitis. In: JB S, editor. Ballenger's Manual of Otorhinolaryngology Head and Neck Surgery. Pmph-usa

2002. p. 254.

6.         Farrokhi S, Gheybi MK, Movahed A, Tahmasebi R, Iranpour D, Fatemi A, et al. Common aeroallergens in patients with asthma and allergic rhinitis living in southwestern part of Iran: based on skin prick test reactivity. Iran J Allergy Asthma Immunol 2015;14(2):133-8.

7.         Werfel T, Asero R, Ballmer-Weber BK, Beyer K, Enrique E, Knulst AC, et al. Position paper of the EAACI: food allergy due to immunological cross-reactions with common inhalant allergens. Allergy 2015;70(9):1079-90.

8.         Sybilski AJ, Zalewska M, Furmanczyk K, Lipiec A, Krzych-Falta E, Samolinski B. The prevalence of sensitization to inhalant allergens in children with atopic dermatitis. Allergy Asthma Proc 2015;36(5):e81-5.

9.         de Vos G, Kravvariti E, Collins J, Tavdy A, Nazari R, Hudes G, et al. Increased allergic sensitization to mugwort in chronic urticaria. Dermatology 2012;225(2):141-6.

10.       Kelly LA, Erwin EA, Platts-Mills TA. The indoor air and asthma: the role of cat allergens. Curr Opin Pulm Med 2012;18(1):29-34.

11.       Burge HA, Rogers CA. Outdoor allergens. Environmental Health Perspectives 2000;108(Suppl 4):653.

12.       Anastassakis K, Chatzimichail A, Androulakis I, Charisoulis S, Riga M, Eleftheriadou A, et al. Skin prick test reactivity to common aeroallergens and ARIA classification of allergic rhinitis in patients of Central Greece. Eur Arch Otorhinolaryngol 2010;267(1):77-85.

13.       Chong Neto HJ, Rosario NA. Studying specific IgE: in vivo or in vitro. Allergol Immunopathol (Madr) 2009;37(1):31-5.

14.       Cox L, Williams B, Sicherer S, Oppenheimer J, Sher L, Hamilton R, et al. Pearls and pitfalls of allergy diagnostic testing: report from the American College of Allergy, Asthma and Immunology/American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force. Ann Allergy Asthma Immunol 2008;101(6):580-92.

15.       Han M, Shin S, Park H, Park KU, Park MH, Song EY. Comparison of three multiple allergen simultaneous tests: RIDA allergy screen, MAST optigen, and polycheck allergy. Biomed Res Int 2013;2013:340513.

16.       Haftenberger M, Laussmann D, Ellert U, Kalcklosch M, Langen U, Schlaud M, et al. [Prevalence of sensitisation to aeraoallergens and food allergens: results of the German Health Interview and Examination Survey for Adults (DEGS1)]. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2013;56(5-6):687-97.

17.       Arbes SJ, Jr., Gergen PJ, Elliott L, Zeldin DC. Prevalences of positive skin test responses to 10 common allergens in the US population: results from the third National Health and Nutrition Examination Survey. J Allergy Clin Immunol 2005;116(2):377-83.

18.       Newson RB, van Ree R, Forsberg B, Janson C, Lotvall J, Dahlen SE, et al. Geographical variation in the prevalence of sensitization to common aeroallergens in adults: the GA(2) LEN survey. Allergy 2014;69(5):643-51.

19.       Assarehzadegan MA, Shakurnia A, Amini A. The most common aeroallergens in a tropical region in Southwestern Iran. World Allergy Organ J 2013;6(1):7.

20.       Hosseini S, Shoormasti RS, Akramian R, Movahedi M, Gharagozlou M, Foroughi N, et al. Skin Prick Test Reactivity to Common Aero and Food Allergens among Children with Allergy. Iran J Med Sci 2014;39(1):29-35.

21.       Bousquet PJ, Castelli C, Daures JP, Heinrich J, Hooper R, Sunyer J, et al. Assessment of allergen sensitization in a general population-based survey (European Community Respiratory Health Survey I). Ann Epidemiol 2010;20(11):797-803.

22.       Stoltz DJ, Jackson DJ, Evans MD, Gangnon RE, Tisler CJ, Gern JE, et al. Specific patterns of allergic sensitization in early childhood and asthma & rhinitis risk. Clin Exp Allergy 2013;43(2):233-41.

23.       Canonica GW, Ansotegui IJ, Pawankar R, Schmid-Grendelmeier P, van Hage M, Baena-Cagnani CE, et al. A WAO - ARIA - GA(2)LEN consensus document on molecular-based allergy diagnostics. World Allergy Organ J 2013;6(1):17.

24.       WEBER RW, Adkinson Jr N, Bochner B, Burks A, Busse W, Holgate S, et al. Aerobiology of outdoor allergens. Middleton's Allergy: Principles and Practice 2013;69:430.

25.       Barne C, Alexis NE, Bernstein JA, Cohn JR, Demain JG, Horner E, et al. Climate change and our environment: the effect on respiratory and allergic disease. J Allergy Clin Immunol Pract 2013;1(2):137-41.

26.       Loureiro G, Rabaca MA, Blanco B, Andrade S, Chieira C, Pereira C. Aeroallergens sensitization in an allergic paediatric population of Cova da Beira, Portugal. Allergol Immunopathol (Madr) 2005;33(4):192-8.

27.       Nowak M, Szymanska A, Grewling L. Allergic risk zones of plane tree pollen (Platanus sp.) in Poznan. Postepy Dermatologii i Alergologii 2012;29(3):156.

28.       Assarehzadegan M-A, Shakurnia AH, Amini A. Sensitization to Common Aeroallergens among Asthmatic Patients in a Tropical Region Affected by Dust Storm. Journal of Medical Sciences 2013;13(7):592-7.

29.       Behmanesh F, Shoja M, Khajedaluee M. Prevalence of aeroallergens in childhood asthma in Mashhad. Macedonian Journal of Medical Sciences 2010;3(3):295-8.

30.       Fereidouni M, Hossini RF, Azad FJ, Assarehzadegan MA, Varasteh A. Skin prick test reactivity to common aeroallergens among allergic rhinitis patients in Iran. Allergol Immunopathol (Madr) 2009;37(2):73-9.

31.       Shirai T, Yasueda H, Saito A, Taniguchi M, Akiyama K, Tsuchiya T, et al. Effect of exposure and sensitization to indoor allergens on asthma control level. Allergol Int 2012;61(1):51-6.

32.       Kashef S, Kashef MA, Eghtedari F. Prevalence of aeroallergens in allergic rhinitis in shiraz. Iran J Allergy Asthma Immunol 2003;2(4):185-8.

33.       Mpairwe H, Muhangi L, Ndibazza J, Tumusiime J, Muwanga M, Rodrigues LC, et al. Skin prick test reactivity to common allergens among women in Entebbe, Uganda. Trans R Soc Trop Med Hyg 2008;102(4):367-73.

34.       Nazario S, Zaragoza R, Velazquez V, Ramos-Valencia G, Acantilado C, Rodriguez R, et al. Allergen sensitivity (mites, insects, and pets) in a Puerto Rican population. P R Health Sci J 2012;31(1):24-8.

35.       Raulf M, Bergmann KC, Kull S, Sander I, Hilger C, Bruning T, et al. Mites and other indoor allergens - from exposure to sensitization and treatment. Allergo J Int 2015;24(3):68-80.

36.       Arruda LK, Barbosa MC, Santos AB, Moreno AS, Chapman MD, Pomes A. Recombinant allergens for diagnosis of cockroach allergy. Curr Allergy Asthma Rep 2014;14(4):428.

37.       Farhoudi A, Pourpak Z, Mesdaghi M, Chavoshzadeh Z, Kazemnejad A. The study of cockroach allergy in Iranian children with asthma. Iranian Journal of Medical Sciences 2015;27(4):156-60.

38.       Safari M AR, Kashef S, Aleyasin S. Cockroach sensitivity in iranian asthmatic children under the age of five years. Tur Toraks 2009;10:26-30.

39.       Langley SJ, Goldthorpe S, Craven M, Morris J, Woodcock A, Custovic A. Exposure and sensitization to indoor allergens: association with lung function, bronchial reactivity, and exhaled nitric oxide measures in asthma. J Allergy Clin Immunol 2003;112(2):362-8.

40.       Majkowska-Wojciechowska B, Pelka J, Korzon L, Kozlowska A, Kaczala M, Jarzebska M, et al. Prevalence of allergy, patterns of allergic sensitization and allergy risk factors in rural and urban children. Allergy 2007;62(9):1044-50.

 


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