Angioedema Due to Lamiaceae Allergy

  • Selçuk Yazıcı Department of Pediatrics, Medical Faculty, Balıkesir University, Balıkesir, Turkey
  • Hikmet Tekin Nacaroglu Department of Pediatrics, Behçet Uz Children Hospital, İzmir, Turkey http://orcid.org/0000-0003-1333-2648
  • Semiha Bahçeci Erdem Department of Pediatrics, Behçet Uz Children Hospital, İzmir, Turkey
  • Sait Karaman Department of Pediatrics, Behçet Uz Children Hospital, İzmir, Turkey
  • Demet Can Division of Pediatric Allergy, Department of Pediatrics, Medical Faculty, Balıkesir University, Balıkesir, Turkey
Keywords: Angioedema, Lamiaceae, Oregano, Sage

Abstract

We present a 13-year-old male childallergic to three different plants (Salvia officinalis, Mentha piperita and Origanum onites L.) of Lamiaceae family. The patient developed angioedema 20-30 minutes after eating chicken meat with cheddar cheese. There was no history of allergy. Oral food challenge (OFC) with both cheddar cheese and chicken meat was negative. Skin tests for inhalant allergens were negative. 3 weeks later, the patient was admitted with angioedema after drinking sage tea. OFC with sage was applied and angioedema was observed. It was recognized that the first trigger, chicken meat with cheddar cheese, included oregano (Origanum onites L.). OFC for oregano was positive. Prick to prick test for Lamiaceae herbs (oregano, sage, mint) was performed. A positive reaction was observed only to mint. OFC was repeated with fresh mint and angioedema developed after 16 hours. Diagnose of Lamiaceae allergy is complicated and cross-sensitivity is common. Skin prick test (prick to prick)revealed a positive response only to mint but not to oregano and sage. Commercial radioallergosorbent (RAST) tests are available only for a few members of the family. Finally, thediagnose is based mainly on OFC. Spices from Lamiaceae group should be considered as potential triggers of allergic reactions.

References

Benito M, Jorro G, Morales C, Peláez A, Fernández A. Labiatae allergy: systemic reactions due to ingestion of oregano and thyme. Ann Allergy Asthma Immunol 1996; 76(5):416-8.Fernandez L, Duque S, Sanchez I, Quiñones D, Rodriguez F, Garcia-Abujeta JL. Allergic contact dermatitis from rosemary (Rosmarinus officinalis L.). Contact Dermatitis 1997; 37(5):248-9Vartholomaios S, Pitsios C, Mikos N, Kompoti E, Kouridakis IS. Allergy to basil, a Lamiaceae herb. J Investig Allergol Clin Immunol 2007; 17(5):348-9.Paiva M, Piedade S, Gaspar A.Toothpaste-induced anaphylaxis caused by mint (Mentha) allergy. Allergy 2010; 65(9):1201-2.Damiani E, Aloia AM, Priore MG, Pastore A, Lippolis C, Lovecchio A, et al. Allergy to mint (Mentha spicata). J Investig Allergol Clin Immunol 2012; 22(4):309-10.Shin TY, Jeong HJ, Jun SM, Chae HJ, Kim HR, Baek SH, et al. Effect of Schizonepeta tenuifolia extract on mast cell-mediated immediate-type hypersensitivity in rats. Immunopharmacol Immunotoxicol 1999; 21(4):705-15Shi TY, Kim HM. Inhibition of immediate-type allergic reactions by the aqueous extract of Salvia plebeia. Immunopharmacol Immunotoxicol. 2002; 24(2):303-14.Kim SH, Park SB, Kang SM, Jeon H, Lim JP, Kwon TK, et al. Anti-allergic effects of Teucrium japonicum on mast cell-mediated allergy model. Food Chem Toxicol 2009; 47(2):398-403.Zhu F, Asada T, Sato A, Koi Y, Nishiwaki H, Tamura H. Rosmarinic acid extract for antioxidant, antiallergic, and α-glucosidase inhibitory activities, isolated by supramolecular technique and solvent extraction from Perilla leaves. J Agric Food Chem 2014; 62(4):885-92.

Published
2018-02-26
How to Cite
1.
Yazıcı S, Nacaroglu H, Bahçeci Erdem S, Karaman S, Can D. Angioedema Due to Lamiaceae Allergy. ijaai. 17(1):97-9.
Section
Case Report(s)